Research & Science
From the molecule to the population: a scientist in public office.
Orazio Schillaci's working life began with research into how radioactive tracers reveal disease. It now concerns how evidence shapes national health policy. This dossier looks at both, and at the Italian research system between them.
Abstract
Schillaci trained as a nuclear medicine physician (Sapienza, 1994) and obtained a doctorate in radioisotopic functional imaging (2000). His research areas, as described in institutional profiles, are nuclear medicine, molecular imaging and image fusion. International speaker profiles credit him with more than 350 peer-reviewed publications and editorial board memberships. Italian press profiles in 2022 counted more than 220 articles indexed in PubMed. He sat on the scientific committee of the Istituto Superiore di Sanità from 2020. As Minister of Health he oversees the main public bodies of Italian health research.
Keywords: nuclear medicine · PET · SPECT · hybrid imaging · molecular imaging · evidence-based policy · ISS · IRCCS
1. The scientific background
Nuclear medicine is one of the most interdisciplinary specialties in medicine. Its practitioners work with radiochemists who synthesise tracers, physicists who build and calibrate detectors, and clinicians who interpret scans alongside the rest of the clinical picture. Research in the field is often translational: a new tracer or imaging protocol is tested in patients and judged by whether it changes diagnosis or treatment.
The three areas named in Schillaci's institutional profiles describe that chain. Nuclear medicine is the clinical discipline. Molecular imaging is the scientific goal of visualising specific biological processes, such as glucose use, receptor expression or cell proliferation. Image fusion is the technique that makes the results clinically useful by placing functional signals on an anatomical map.
2. The publication record
Two figures appear in public profiles: more than 350 peer-reviewed publications (OECD speaker profile) and more than 220 articles in PubMed (Italian press, 2022). The difference is mainly one of method. PubMed indexes biomedical journals, while broader counts include other indexed outputs. This site does not list or summarise individual papers. Readers who want the primary literature should search PubMed or Scopus by author name.
Public scrutiny of a scientist-minister's record is legitimate, and the research literature remains the place to examine it.
3. Evidence-based policy
Evidence-based policy applies the logic of evidence-based medicine to decisions about populations: what does the best available evidence say, how certain is it, and what are the trade-offs? In a health ministry it shapes decisions on what to include in the essential levels of care, which screening programmes to fund and which vaccines to recommend.
The Minister has repeatedly linked resources to results. In October 2026 he said that what matters is not only how much is spent but "how" it is spent and what health outcomes it produces. That position requires measurement, which is why national monitoring platforms for waiting lists and the LEA, and the structured data of the FSE 2.0, are part of the same agenda.
4. Health research and medical technology
Italy's public health research rests on a few pillars: the Istituto Superiore di Sanità, the national public health institute founded in 1934; the IRCCS network of research hospitals recognised by the Ministry of Health; the universities and their teaching hospitals; and the Ministry's own competitive research funding (ricerca finalizzata). Medical technology links research to care, from the diagnostic equipment financed by the PNRR to new medicines evaluated by AIFA.
International cooperation is part of the same system. At the 2024 G7 in Ancona, Italy committed $21 million to research and development of new antibiotics, a field where market incentives have long been too weak to sustain investment.
The research ecosystem
Institutions of Italian health science.
References
- OECD Health Ministerial Meeting, speaker profile: Orazio Schillaci. oecd-events.org
- "Orazio Schillaci", Wikipedia (Italian and English editions) and the press sources cited there (Adnkronos, Sky TG24, 2022). en.wikipedia.org
- University of Rome Tor Vergata, "Former Rector of Tor Vergata University appointed Italian Minister of Health". uniroma2.it
- Quotidiano Sanità, UnoMattina interview coverage, October 2026. quotidianosanita.it
- Avvenire, "G7 Salute, la sfida globale si chiama One Health". avvenire.it